My research project focuses on immune stimulation of immune cells in cancer. We hope to use this approach to turn immune "cold" tumors "hot"; which enhances tumor responses to immunotherapy. A key signaling pathway that we are attempting to activate is the non-canonical NFkB. We believe that specific activation of this pathway can efficiently activate immune responses against tumors, and thus make tumors "hot". We plan to test these hypotheses in mouse models of cancer by using an immune stimulatory lipid nanoparticle approach, with the broader goal of developing novel immunotherapies to treat cancer.