Research thoughts by:

Debattama Sen

Thank you!


I am extraordinarily honored to be awarded this year’s Karin Grunebaum Cancer Research Fellowship, and am excited about the new avenues this will enable in our group. I’m so thankful, both to the Grunebaum family and the Board of the Foundation, for this wonderful opportunity!

My lab officially opened its doors at MGH Navy Yard in December 2020. We are investigating the regulation of T cell dysfunction and exploring epigenetic approaches for T cell engineering to improve the treatment of cancer. Our work lies at the interface of human immunology, systems biology, and functional epigenomics – merging clinical observations with mechanistic mouse studies to develop novel therapeutic strategies. I'm excited to share updates on our progress over the next year as we study the epigenetic regulation and functional consequences of chronic PD-1 expression in anti-tumor immunity.