Focus of Research: Lymphoma Oncogene/Tumor Suppressor Gene Discovery
Harvard Medical School
Co-Authors Gaudet R, Tortorella D, Wang EW, Ploegh HL
Over the past year, we have witnessed the discovery of further virus immuno-evasins--proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.
Curr Opin Immunol. 2001 Aug;13(4):442-50